Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers

Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a variety of cancers. However, a novel therapeutic approach is needed...

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Bibliographic Details
Main Authors: Takefumi Komiya, Chao H. Huang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
immuno-oncology
IDO (indoleamine 2,3-dioxygenase)
PD-1
tryptophan
clinical trials as topic
IDO1 inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00423/full
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