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Tissue-Specific Ablation of Prkar1a Causes Schwannomas by Suppressing Neurofibromatosis Protein Production

Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRK...

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Bibliografski detalji
Glavni autori: Georgette N. Jones, Chhavy Tep, William H. Towns, II, Georgeta Mihai, Ian D. Tonks, Graham F. Kay, Petra M. Schmalbrock, Anat O. Stemmer-Rachamimov, Sung Ok Yoon, Lawrence S. Kirschner
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2008-11-01
Serija:Neoplasia: An International Journal for Oncology Research
Online pristup:http://www.sciencedirect.com/science/article/pii/S1476558608800188
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