Transmembrane protein 108 inhibits the proliferation and myelination of oligodendrocyte lineage cells in the corpus callosum

Abstract Background Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of bipolar disorder, is expressed higher in OL lineage cells than any...

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Main Authors: Yongqiang Wu, Yanzi Zhong, Xufeng Liao, Xiangguang Miao, Jianbo Yu, Xinsheng Lai, Yu Zhang, Chaolin Ma, Haili Pan, Shunqi Wang
Format: Artigo
Jezik:Inglês
Izdano: BMC 2022-04-01
Serija:Molecular Brain
Teme:
Tmem108
Oligodendrocyte (OL)
Myelination
Corpus callosum (CC)
Bipolar disorder (BD)
Online dostop:https://doi.org/10.1186/s13041-022-00918-7
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