Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes

Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. RIPK1 regulates inflammation and cell death by interacting with receptor-interacting serine/threonine protein kinases 3(RIPK3). We hypoth...

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Bibliographic Details
Main Authors: Shuang Liang, Zheng-tao Lv, Jia-ming Zhang, Yu-ting Wang, Yong-hui Dong, Zheng-gang Wang, Kun Chen, Peng Cheng, Qing Yang, Feng-jing Guo, Wei-wei Lu, Wen-tao Zhu, An-min Chen
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
necrostatin-1
osteoarthritis
chondrocyte
necroptosis
apoptosis
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01378/full
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