Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650

Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in vitro models are required. Here, porcine olfactory (OEPC) and respiratory (REPC) primary cells were characteris...

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מידע ביבליוגרפי
Main Authors: Simone Ladel, Patrick Schlossbauer, Johannes Flamm, Harald Luksch, Boris Mizaikoff, Katharina Schindowski
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2019-08-01
סדרה:Pharmaceutics
נושאים:
barrier model
nose-to-brain
primary cells
RPMI 2650
olfactory epithelium
respiratory epithelium
גישה מקוונת:https://www.mdpi.com/1999-4923/11/8/367
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