Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650

Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal drug delivery. With increasing interest for intranasal pathways, adequate in vitro models are required. Here, porcine olfactory (OEPC) and respiratory (REPC) primary cells were characteris...

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Bibliographic Details
Main Authors: Simone Ladel, Patrick Schlossbauer, Johannes Flamm, Harald Luksch, Boris Mizaikoff, Katharina Schindowski
Format: Artigo
Language:Inglês
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
barrier model
nose-to-brain
primary cells
RPMI 2650
olfactory epithelium
respiratory epithelium
Online Access:https://www.mdpi.com/1999-4923/11/8/367
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