Association of Bax expression and Bcl2/Bax ratio with clinical and molecular prognostic markers in chronic lymphocytic leukemia

Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery. These include genetic alterations and aberrant expression of many apoptosis regulators, among which the Bcl2 family me...

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Hlavní autoři: Vučićević Ksenija, Jakovljević Vladimir, Čolović Nataša, Tošić Nataša, Kostić Tatjana, Glumac Irena, Pavlović Sonja, Karan-Đurašević Teodora, Čolović Milica
Médium: Artigo
Jazyk:Inglês
Vydáno: Society of Medical Biochemists of Serbia, Belgrade 2016-01-01
Edice:Journal of Medical Biochemistry
Témata:
apoptosis
bax
bcl2/bax ratio
chronic lymphocytic leukemia
expression analysis
On-line přístup:https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2016/1452-82581602150V.pdf
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