Tyrphostin AG17 inhibits adipocyte differentiation in vivo and in vitro

Abstract Background Excessive subcutaneous adiposity in obesity is associated to positive white adipocyte tissue (WAT) differentiation (adipogenesis) and WAT expandability. Here, we hypothesized that supplementation with the insulin inhibitor and mitochondrial uncoupler, Tyrphostin (T-AG17), in vitr...

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Autors principals: Alberto Camacho, Juan Carlos Segoviano-Ramírez, Adriana Sánchez-Garcia, Jose de Jesus Herrera-de la Rosa, Jaime García-Juarez, Carlos Alberto Hernandez-Puente, Geovana Calvo-Anguiano, Sergio Rodolfo Maltos-Uro, Alejandra Olguin, Gabriel Gojon-Romanillos, Gabriel Gojon-Zorrilla, Rocio Ortiz-Lopez
Format: Artigo
Idioma:Inglês
Publicat: BMC 2018-05-01
Col·lecció:Lipids in Health and Disease
Matèries:
Tyrphostin
AG17
Adipogenesis
Obesity
Hepatic steatosis
Oxidative phosphorylation
Accés en línia:http://link.springer.com/article/10.1186/s12944-018-0784-7
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