Association Between Promoter Polymorphisms in CD46 and CD59 in Kidney Donors and Transplant Outcome

Complement regulating proteins, including CD46, CD55, and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be involved in accommodation. Polymorphisms in their promoter regions may affect their expression. The aim of this study w...

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Autori principali: Laura A. Michielsen, Arjan D. van Zuilen, Tineke Kardol-Hoefnagel, Marianne C. Verhaar, Henny G. Otten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018-05-01
Serie:Frontiers in Immunology
Soggetti:
complement regulatory proteins
promoter regions
genetic
kidney donor
graft survival
acute rejection
Accesso online:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00972/full
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