Discovery of cytotoxic indolo[1,2-c]quinazoline derivatives through scaffold-based design

Indolo[1,2-c]quinazoline derivatives have emerged as promising chemotype in drug discovery due to their versatile biological activities, including antimicrobial and antiviral properties. In this study, we report the design, synthesis, and biological evaluation of novel indolo[1,2-c]quinazoline deriv...

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Detalhes bibliográficos
Main Authors: Daniil V. Khabarov, Valeria A. Litvinova, Lyubov G. Dezhenkova, Dmitry N. Kaluzhny, Alexander S. Tikhomirov, Andrey E. Shchekotikhin
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2025-10-01
Colecção:Beilstein Journal of Organic Chemistry
Assuntos:
antiproliferative activity
antitumor agents
indolo[1,2-c]quinazoline
modification
structure–activity relationship
Acesso em linha:https://doi.org/10.3762/bjoc.21.161
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