Inflammatory mediators and the RAGE pathway in placental tissues of pregnancies complicated by severe preeclampsia

IntroductionPreeclampsia (PE) is a complex multisystem disorder of pregnancy associated with abnormal placentation, vascular anomalies, and systemic inflammation and hypertension. Previous research assessing inflammatory triggers of the condition used plasma, amniotic fluid, or explant samples. Stud...

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Hlavní autoři: Neelima Chandra, Thomas D. Kimble, Kathleen R. Heim, Sharon M. Anderson, Andrew P. Wong, Andrea R. Thurman, Gustavo F. Doncel
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2025-08-01
Edice:Frontiers in Reproductive Health
Témata:
calcium binding protein (S-100)
cyclooxygenase 2 (COX-2)
high mobility group box protein (HMGB1)
interleukin 8 (IL-8)
nuclear factor kappa B p65 sub unit (NF-kBp65)
receptors of advanced glycation end products (RAGE)
On-line přístup:https://www.frontiersin.org/articles/10.3389/frph.2025.1587699/full
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