Inflammatory mediators and the RAGE pathway in placental tissues of pregnancies complicated by severe preeclampsia

IntroductionPreeclampsia (PE) is a complex multisystem disorder of pregnancy associated with abnormal placentation, vascular anomalies, and systemic inflammation and hypertension. Previous research assessing inflammatory triggers of the condition used plasma, amniotic fluid, or explant samples. Stud...

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Detalhes bibliográficos
Main Authors: Neelima Chandra, Thomas D. Kimble, Kathleen R. Heim, Sharon M. Anderson, Andrew P. Wong, Andrea R. Thurman, Gustavo F. Doncel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-08-01
Colecção:Frontiers in Reproductive Health
Assuntos:
calcium binding protein (S-100)
cyclooxygenase 2 (COX-2)
high mobility group box protein (HMGB1)
interleukin 8 (IL-8)
nuclear factor kappa B p65 sub unit (NF-kBp65)
receptors of advanced glycation end products (RAGE)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/frph.2025.1587699/full
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