Ranolazine and late cardiac sodium current – a therapeutic target for angina, arrhythmia and more?

by Makielski, Jonathan C, Valdivia, Carmen R
Published 2006

Tetracaine derivatives for catecholaminergic polymorphic ventricular tachycardia: new drugs for correction of diastolic Ca(2+) leak?

by Valdivia, Héctor H., Valdivia, Carmen R.
Published in Heart Rhythm (2018)

Navigating the sea of long non-coding RNAs: ZFAS1, friend or foe?

by Alvarado, Francisco J., Valdivia, Carmen R., Valdivia, Héctor H.
Published in Circ Res (2018)

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

by Valdivia, Carmen R., Ueda, Kazuo, Ackerman, Michael J., Makielski, Jonathan C.
Published 2009

Arrhythmogenic mechanisms in ryanodine receptor channelopathies

by ZHAO, Yan-Ting, VALDIVIA, Carmen R., GURROLA, Georgina B., HERNÁNDEZ, Jonathan J., VALDIVIA, Héctor H.
Published in Sci China Life Sci (2014)

Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A

by Cheng, Jianding, Valdivia, Carmen R., Vaidyanathan, Ravi, Balijepalli, Ravi C., Ackerman, Michael J., Makielski, Jonathan C.
Published 2013

Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle

by Chutkow, William A., Samuel, Varman, Hansen, Polly A., Pu, Jielin, Valdivia, Carmen R., Makielski, Jonathan C., Burant, Charles F.
Published 2001

Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome

by Hu, Rou-Mu, Tan, Bi-Hua, Orland, Kate M., Valdivia, Carmen R., Peterson, Amber, Pu, Jielin, Makielski, Jonathan C.
Published 2013

Loss-of-function mutation of the SCN3B-encoded sodium channel β3 subunit associated with a case of idiopathic ventricular fibrillation

by Valdivia, Carmen R., Medeiros-Domingo, Argelia, Ye, Bin, Shen, Win-Kuang, Algiers, Timothy J., Ackerman, Michael J., Makielski, Jonathan C.
Published 2010

Molecular and Functional Characterization of Novel Glycerol-3-Phosphate Dehydrogenase 1–Like Gene (GPD1-L) Mutations in Sudden Infant Death Syndrome

by Van Norstrand, David W., Valdivia, Carmen R., Tester, David J., Ueda, Kazuo, London, Barry, Makielski, Jonathan C., Ackerman, Michael J.
Published 2007

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca(2+) release

by Liu, Bin, Ho, Hsiang-Ting, Velez-Cortes, Florencia, Lou, Qing, Valdivia, Carmen R, Knollmann, Bjorn C, Valdivia, Hector H, Gyorke, Sandor
Published in J Physiol (2014)

The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current

by Cheng, Jianding, Tester, David J., Tan, Bi-Hua, Valdivia, Carmen R., Kroboth, Stacie, Ye, Bin, January, Craig T., Ackerman, Michael J., Makielski, Jonathan C.
Published 2011

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

by Zhao, Yan-Ting, Valdivia, Carmen R., Gurrola, Georgina B., Powers, Patricia P., Willis, B. Cicero, Moss, Richard L., Jalife, José, Valdivia, Héctor H.
Published in Proc Natl Acad Sci U S A (2015)

Structure–function relationships of peptides forming the calcin family of ryanodine receptor ligands

by Xiao, Liang, Gurrola, Georgina B., Zhang, Jing, Valdivia, Carmen R., SanMartin, Mario, Zamudio, Fernando Z., Zhang, Liming, Possani, Lourival D., Valdivia, Héctor H.
Published in J Gen Physiol (2016)

Sudden Infant Death Syndrome-Associated Mutations in the Sodium Channel Beta Subunits

by Tan, Bi-Hua, Pundi, Kavitha N, Van Norstrand, David W, Valdivia, Carmen R, Tester, David J, Medeiros-Domingo, Argelia, Makielski, Jonathan C., Ackerman, Michael J.
Published 2010

A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia

by Tan, Bi-Hua, Iturralde-Torres, Pedro, Medeiros-Domingo, Argelia, Nava, Santiago, Tester, David J, Valdivia, Carmen R., Tusié-Luna, Teresa, Ackerman, Michael J., Makielski, Jonathan C.
Published 2007

LQTS-associated mutation A257G in α1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype

by Cheng, Jianding, Norstrand, David W. Van, Medeiros-Domingo, Argelia, Tester, David J., Valdivia, Carmen R., Tan, Bi-Hua, Vatta, Matteo, Makielski, Jonathan C., Ackerman, Michael J.
Published 2011

Enhanced Classification of Brugada Syndrome–Associated and Long-QT Syndrome–Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel

by Kapplinger, Jamie D., Giudicessi, John R., Ye, Dan, Tester, David J., Callis, Thomas E., Valdivia, Carmen R., Makielski, Jonathan C., Wilde, Arthur A., Ackerman, Michael J.
Published in Circ Cardiovasc Genet (2015)

Atrial Infarction-Induced Spontaneous Focal Discharges and Atrial Fibrillation in Sheep: Role of Dantrolene-Sensitive Aberrant Ryanodine Receptor Calcium Release

by Avula, Uma Mahesh R., Hernandez, Jonathan J., Yamazaki, Masatoshi, Valdivia, Carmen R., Chu, Antony, Rojas-Pena, Alvaro, Kaur, Kuljeet, Ramos-Mondragón, Roberto, Anumonwo, Justus M., Nattel, Stanley, Valdivia, Héctor H., Kalifa, Jérôme
Published in Circ Arrhythm Electrophysiol (2018)

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2

by Alvarado, Francisco J., Bos, J. Martijn, Yuchi, Zhiguang, Valdivia, Carmen R., Hernández, Jonathan J., Zhao, Yan-Ting, Henderlong, Dawn S., Chen, Yan, Booher, Talia R., Marcou, Cherisse A., Van Petegem, Filip, Ackerman, Michael J., Valdivia, Héctor H.
Published in JCI Insight (2019)