Resultats de la cerca - Timothy Palzkill

Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases per Timothy Palzkill, Timothy Palzkill

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Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1 per Zhizeng Sun, Timothy Palzkill

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Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. per Shrenik C Mehta, Kacie Rice, Timothy Palzkill

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How structural and physicochemical determinants shape sequence constraints in a functional enzyme. per Luciano A Abriata, Timothy Palzkill, Matteo Dal Peraro

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Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics per Zhizeng Sun, Liya Hu, Banumathi Sankaran, B. V. Venkataram Prasad, Timothy Palzkill

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Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from <named-content content-type="genus-species">Klebsiella pneumoniae</named-c... per Shuo Lu, Victoria Soeung, Hoang A. T. Nguyen, S. Wesley Long, James M. Musser, Timothy Palzkill

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Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response per Lynn Su, Wanzhi Huang, Frederick H. Neill, Mary K. Estes, Robert L. Atmar, Timothy Palzkill

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Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses. per Amy M Hurwitz, Wanzhi Huang, Baijun Kou, Mary K Estes, Robert L Atmar, Timothy Palzkill

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Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase per Allison Judge, Liya Hu, Banumathi Sankaran, Justin Van Riper, B. V. Venkataram Prasad, Timothy Palzkill

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The binary protein interactome of Treponema pallidum--the syphilis spirochete. per Björn Titz, Seesandra V Rajagopala, Johannes Goll, Roman Häuser, Matthew T McKevitt, Timothy Palzkill, Peter Uetz

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Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis. per Haichun Gao, Xiaohu Wang, Zamin K Yang, Jingrong Chen, Yili Liang, Haijiang Chen, Timothy Palzkill, Jizhong Zhou

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Reduced catalytic activity of KPC β-lactamase can increase ceftazidime resistance per André Birgy, Dignite Fabrice Ngango, Murugesan Palaniappan, Shahlo O. Solieva, Devin G. Kelly, Zhizeng Sun, Gregory Bowman, Timothy Palzkill

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An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes per Shuo Lu, Liya Hu, Hanfeng Lin, Allison Judge, Paola Rivera, Murugesan Palaniappan, Banumathi Sankaran, Jin Wang, B. V. Venkataram Prasad, Timothy Palzkill

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Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline per Jacob E. Choby, Tugba Ozturk, Carter N. Abbott, Christina Nnabuife, Jennifer M. Colquhoun, Sarah W. Satola, Philip N. Rather, Timothy Palzkill, David S. Weiss

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Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors per Son Pham, Boyang Zhao, Neetu Neetu, Banumathi Sankaran, Ketki Patil, Sasirekha Ramani, Yongcheng Song, Mary K. Estes, Timothy Palzkill, B. V. Venkataram Prasad

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The protein network of bacterial motility per Seesandra V Rajagopala, Björn Titz, Johannes Goll, Jodi R Parrish, Katrin Wohlbold, Matthew T McKevitt, Timothy Palzkill, Hirotada Mori, Russell L Finley, Peter Uetz

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Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. per Fei Yan, Yang Yu, Dar-Chone Chow, Timothy Palzkill, Franck Madoux, Peter Hodder, Peter Chase, Patrick R Griffin, Bert W O'Malley, David M Lonard

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Generation and validation of a Shewanella oneidensis MR-1 clone set for protein expression and phage display. per Haichun Gao, Donna Pattison, Tingfen Yan, Dawn M Klingeman, Xiaohu Wang, Joseph Petrosino, Lisa Hemphill, Xiufeng Wan, Adam B Leaphart, George M Weinstock, Timothy Palzkill, Jizhong Zhou

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Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. per Jeong Joo Kim, Darren E Casteel, Gilbert Huang, Taek Hun Kwon, Ronnie Kuo Ren, Peter Zwart, Jeffrey J Headd, Nicholas Gene Brown, Dar-Chone Chow, Timothy Palzkill, Choel Kim

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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters per Margie N. Sutton, Zhen Lu, Yao-Cheng Li, Yong Zhou, Tao Huang, Albert S. Reger, Amy M. Hurwitz, Timothy Palzkill, Craig Logsdon, Xiaowen Liang, Joe W. Gray, Xiaolin Nan, John Hancock, Geoffrey M. Wahl, Robert C. Bast, Jr.

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