Resultados da busca - Stuart A. Cook

Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle? por Mark Sweeney, Ben Corden, Stuart A Cook

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Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy por Anissa A. Widjaja, Sonia P. Chothani, Stuart A. Cook

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Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts por Anissa A. Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K. Singh, Jessie Tan, Joyce Goh Wei Ting, David Lamb, Shamini G. Shekeran, Benjamin L. George, Sebastian Schafer, David Carling, Eleonora Adami, Stuart A. Cook, Stuart A. Cook, Stuart A. Cook

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Sacubitril/valsartan versus valsartan in regressing myocardial fibrosis in hypertension: a prospective, randomized, open-label, blinded endpoint clinical trial protocol por Vivian Lee, Qishi Zheng, Desiree-Faye Toh, Chee Jian Pua, Jennifer A. Bryant, Chi-Hang Lee, Stuart A. Cook, Stuart A. Cook, Stuart A. Cook, Javed Butler, Javed Butler, Javier Díez, Javier Díez, A. Mark Richards, A. Mark Richards, Thu-Thao Le, Thu-Thao Le, Calvin W. L. Chin, Calvin W. L. Chin, Calvin W. L. Chin

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling por Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja, Stuart A Cook

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IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells por Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook

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Truncations of the titin Z-disc predispose to a heart failure with preserved ejection phenotype in the context of pressure overload. por Lei Ye, Liping Su, Chenxu Wang, Szejie Loo, Guizhen Tee, Shihua Tan, Sandar Win Khin, Shijie Ko, Boyang Su, Stuart A Cook

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EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes. por Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A Cook, Joan X Comella, Daniel Sanchis

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Genome-wide co-expression analysis in multiple tissues. por Ian C Grieve, Nicholas J Dickens, Michal Pravenec, Vladimir Kren, Norbert Hubner, Stuart A Cook, Timothy J Aitman, Enrico Petretto, Jonathan Mangion

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Fractal analysis of left ventricular trabeculations is associated with impaired myocardial deformation in healthy Chinese por Jiashen Cai, Jennifer Ann Bryant, Thu-Thao Le, Boyang Su, Antonio de Marvao, Declan P. O’Regan, Stuart A. Cook, Calvin Woon-Loong Chin

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Evaluation of family health history collection methods impact on data and risk assessment outcomes por R. Ryanne Wu, Rehena Sultana, Yasmin Bylstra, Saumya Jamuar, Sonia Davila, Weng Khong Lim, Geoffrey S. Ginsburg, Lori A. Orlando, Khung Keong Yeo, Stuart A. Cook, Patrick Tan

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New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. por Enrico Petretto, Leonardo Bottolo, Sarah R Langley, Matthias Heinig, Chris McDermott-Roe, Rizwan Sarwar, Michal Pravenec, Norbert Hübner, Timothy J Aitman, Stuart A Cook, Sylvia Richardson

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Heritability and tissue specificity of expression quantitative trait loci. por Enrico Petretto, Jonathan Mangion, Nicholas J Dickens, Stuart A Cook, Mande K Kumaran, Han Lu, Judith Fischer, Henrike Maatz, Vladimir Kren, Michal Pravenec, Norbert Hubner, Timothy J Aitman

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Towards clinical molecular diagnosis of inherited cardiac conditions: a comparison of bench-top genome DNA sequencers. por Xinzhong Li, Andrew J Buckton, Samuel L Wilkinson, Shibu John, Roddy Walsh, Tomas Novotny, Iveta Valaskova, Manu Gupta, Laurence Game, Paul J R Barton, Stuart A Cook, James S Ware

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A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model por David Schumacher, Elisa A. Liehn, Pakhwan Nilcham, David Castaño Mayan, Chutima Rattanasopa, Kaviya Anand, Gustavo E. Crespo-Avilan, Sauri Hernandez-Resendiz, Roshni R. Singaraja, Stuart A. Cook, Derek J. Hausenloy

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Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration por Benjamin Ng, Kevin Y. Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim, Fathima F. Kuthubudeen, Yu-Ning Liu, An An Hii, Benjamin L. George, Anissa A. Widjaja, Enrico Petretto, Stuart A. Cook

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Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case–control study por Emanuele F. Osimo, Mark Sweeney, Antonio de Marvao, Alaine Berry, Ben Statton, Benjamin I. Perry, Toby Pillinger, Thomas Whitehurst, Stuart A. Cook, Declan P. O’Regan, E. Louise Thomas, Oliver D. Howes

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A comparative study of mutation screening of sarcomeric genes (MYBPC3, MYH7, TNNT2) using single gene approach versus targeted gene panel next generation sequencing in a cohort of... por Heba Sh. Kassem, Roddy Walsh, Paul J. Barton, Besra S. Abdelghany, Remon S. Azer, Rachel Buchan, Shibu John, Ahmed Elguindy, Sarah Moharem-ElGamal, Hala M. Badran, Hoda Shehata, Stuart A. Cook, Magdi H. Yacoub

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Noninvasive Mapping of the Electrophysiological Substrate in Cardiac Amyloidosis and Its Relationship to Structural Abnormalities por Michele Orini, Adam J. Graham, Ana Martinez‐Naharro, Christopher M. Andrews, Antonio de Marvao, Ben Statton, Stuart A. Cook, Declan P. O'Regan, Philip N. Hawkins, Yoram Rudy, Marianna Fontana, Pier D. Lambiase

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Paradoxical Higher Myocardial Wall Stress and Increased Cardiac Remodeling Despite Lower Mass in Females por Andrew I. H. Phua, Thu‐Thao Le, Su W. Tara, Antonio De Marvao, Jinming Duan, Desiree‐Faye Toh, Briana Ang, Jennifer A. Bryant, Declan P. O'Regan, Stuart A. Cook, Calvin W. L. Chin

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