Resultados da busca - Steven P Angus

Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition por Evan DuBose, Evan DuBose, Samantha M. Bevill, Samantha M. Bevill, Dana K. Mitchell, Noah Sciaky, Brian T. Golitz, Shelley A. H. Dixon, Steven D. Rhodes, Steven D. Rhodes, Steven D. Rhodes, Steven D. Rhodes, James E. Bear, James E. Bear, James E. Bear, Gary L. Johnson, Gary L. Johnson, Steven P. Angus, Steven P. Angus, Steven P. Angus, Steven P. Angus, Steven P. Angus

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Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies por Adedeji K. Adebayo, Poornima Bhat-Nakshatri, Christopher Davis, Steven P. Angus, Cihat Erdogan, Hongyu Gao, Nick Green, Brijesh Kumar, Yunlong Liu, Harikrishna Nakshatri

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SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2 por Gaurav A. Mehta, Steven P. Angus, Christen A. Khella, Kevin Tong, Pooja Khanna, Shelley A. H. Dixon, Michael P. Verzi, Gary L. Johnson, Michael L. Gatza

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Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Tr... por Timothy J. Stuhlmiller, Jon S. Zawistowski, Xin Chen, Noah Sciaky, Steven P. Angus, Sean T. Hicks, Traci L. Parry, Wei Huang, Ju Youn Beak, Monte S. Willis, Gary L. Johnson, Brian C. Jensen

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RIPK1 regulates β-cell fate via actions on gene expression and kinase signaling in a mouse model of β-cell self-reactivity por Christopher J. Contreras, Noyonika Mukherjee, Arianna Harris-Kawano, Egan G. Mather, Nansalmaa Amarsaikhan, Christopher Davis, Christine A. Berryhill, Madeline Peyton, Debjyoti Kundu, Kaitlyn A. Colglazier, Addison S. Miller, Renato C. S. Branco, Travis S. Johnson, Steven P. Angus, Sylvaine You, Erica P. Cai, Andrew T. Templin

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A haploinsufficiency restoration strategy corrects neurobehavioral deficits in Nf1+/– mice por Su Jung Park, Jodi L. Lukkes, Ka-Kui Chan, Hayley P. Drozd, Callie B. Burgin, Shaomin Qian, Morgan McKenzie Sullivan, Cesar Gabriel Guevara, Nolen Cunningham, Stephanie Arenas, Makenna A. Collins, Jacob Zucker, JinHee Won, Abbi Smith, Li Jiang, Dana K. Mitchell, Steven D. Rhodes, Steven P. Angus, D. Wade Clapp

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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy por Chialin Cheng, Surya A. Reis, Emily T. Adams, Daniel M. Fass, Steven P. Angus, Timothy J. Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T. Wang, Debasis Patnaik, Roberta L. Beauchamp, Danielle A. Feldman, M. Catarina Silva, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Bruce L. Miller, Sally Temple, Kenneth S. Kosik, Bradford C. Dickerson, Stephen J. Haggarty

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Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains por Timothy J. Stuhlmiller, Samantha M. Miller, Jon S. Zawistowski, Kazuhiro Nakamura, Adriana S. Beltran, James S. Duncan, Steven P. Angus, Kyla A.L. Collins, Deborah A. Granger, Rachel A. Reuther, Lee M. Graves, Shawn M. Gomez, Pei-Fen Kuan, Joel S. Parker, Xin Chen, Noah Sciaky, Lisa A. Carey, H. Shelton Earp, Jian Jin, Gary L. Johnson

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Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma por Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari, C. Ryan Miller

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FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036 por Steven P. Angus, Timothy J. Stuhlmiller, Gaurav Mehta, Samantha M. Bevill, Daniel R. Goulet, J. Felix Olivares-Quintero, Michael P. East, Maki Tanioka, Jon S. Zawistowski, Darshan Singh, Noah Sciaky, Xin Chen, Xiaping He, Naim U. Rashid, Lynn Chollet-Hinton, Cheng Fan, Matthew G. Soloway, Patricia A. Spears, Stuart Jefferys, Joel S. Parker, Kristalyn K. Gallagher, Andres Forero-Torres, Ian E. Krop, Alastair M. Thompson, Rashmi Murthy, Michael L. Gatza, Charles M. Perou, H. Shelton Earp, Lisa A. Carey, Gary L. Johnson

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Dual CDK4/6–PI3K/mTOR inhibition reinforces cytostatic programs and tumor control in preclinical models of primary and metastatic osteosarcoma por Farinaz Barghi, M. Reza Saadatzadeh, Erika A. Dobrota, Harlan E. Shannon, Barbara J. Bailey, Courtney Young, Rada Malko, Ryli Justice, Niknam Riyahi, Christopher Davis, Khadijeh Bijangi-Vishehsaraei, Keiko Kreklau, Lauren K. Stevens, Jenna Koenig, Shirzat Sulayman, Sheng Liu, Jun Wan, Melissa A. Trowbridge, Kathy Coy, Felicia M. Kennedy, Anthony L. Sinn, Marissa Just, Kyle W. Jackson, George Sandusky, L. Daniel Wurtz, Christopher D. Collier, Dana Mitchell, Emily E. Seiden, Edward M. Greenfield, Emma Doud, Amber Mosley, Steven P. Angus, Michael J. Ferguson, Pankita H. Pandya, Karen E. Pollok

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Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK. por Long-Sheng Chang, Janet L Oblinger, Abbi E Smith, Marc Ferrer, Steven P Angus, Eric Hawley, Alejandra M Petrilli, Roberta L Beauchamp, Lars Björn Riecken, Serkan Erdin, Ming Poi, Jie Huang, Waylan K Bessler, Xiaohu Zhang, Rajarshi Guha, Craig Thomas, Sarah S Burns, Thomas S K Gilbert, Li Jiang, Xiaohong Li, Qingbo Lu, Jin Yuan, Yongzheng He, Shelley A H Dixon, Andrea Masters, David R Jones, Charles W Yates, Stephen J Haggarty, Salvatore La Rosa, D Bradley Welling, Anat O Stemmer-Rachamimov, Scott R Plotkin, James F Gusella, Justin Guinney, Helen Morrison, Vijaya Ramesh, Cristina Fernandez-Valle, Gary L Johnson, Jaishri O Blakeley, D Wade Clapp, Synodos for NF2 Consortium

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