Resultats de la cerca - Richard T. Timms

Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression per Dylan E. Ramage, Drew W. Grant, Richard T. Timms

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ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex per Richard T. Timms, Iva A. Tchasovnikarova, Robin Antrobus, Gordon Dougan, Paul J. Lehner

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Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells. per Lidia M Duncan, Richard T Timms, Eszter Zavodszky, Florencia Cano, Gordon Dougan, Felix Randow, Paul J Lehner

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Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms per Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner, Yorgo Modis

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The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1 per Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner

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Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases. per Richard T Timms, Lidia M Duncan, Iva A Tchasovnikarova, Robin Antrobus, Duncan L Smith, Gordon Dougan, Michael P Weekes, Paul J Lehner

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Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens per Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner

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Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase per Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T. Timms, Xuebiao Yao, Stephen J. Elledge, Itay Koren, Kaiming Zhang, Chao Xu

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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control per Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis

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