CD14+ cells CTLA-4 HCC PD-1 PD-1 antibody PD-L1 PD-L1 antibody TACE TCGA a disintegrin and metalloprotease 9 alpha fetoprotein response anti-VEGF inhibitor bic Book Industry Communication::M Medicine bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology biomarkers cancer immunotherapy check-point inhibitors combination immunotherapy combination therapies combination therapy copy number variations effectiveness electroconvulsive therapy (ECT) genetic alteration hepatocellular carcinoma hepatocellular carcinoma (HCC) immune checkpoint blockade immune checkpoint inhibition immune checkpoint inhibitor immune phenotype