نتائج البحث - Mark R Cookson

Molecules that cause or prevent Parkinson's disease. حسب Mark R Cookson

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Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions حسب Elisa Greggio, Mark R Cookson

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How Parkinson’s Disease-Linked LRRK2 Mutations Affect Different CNS Cell Types حسب Hannah M. Bailey, Mark R. Cookson

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Specific Detection of Physiological S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay حسب Ryan Arlinghaus, Michiyo Iba, Eliezer Masliah, Mark R. Cookson, Natalie Landeck

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Imaging spatial transcriptomics reveals molecular patterns underlying accumulation of p-Ser129 α-synuclein in a transgenic mouse model حسب Liam Horan-Portelance, Michiyo Iba, Dominic J. Acri, J. Raphael Gibbs, Mark R. Cookson

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Structure and regulation of full-length human leucine-rich repeat kinase 1 حسب Riley D. Metcalfe, Juliana A. Martinez Fiesco, Luis Bonet-Ponce, Jillian H. Kluss, Mark R. Cookson, Ping Zhang

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Combined Knockout of and Does Not Result in Behavioral Abnormalities حسب Melissa Conti Mazza, Victoria Nguyen, Alexandra Beilina, Ema Karakoleva, Michael Coyle, Jinhui Ding, Christopher Bishop, Mark R. Cookson

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Variant biomarker discovery using mass spectrometry-based proteogenomics حسب Luke Reilly, Sahba Seddighi, Andrew B. Singleton, Andrew B. Singleton, Mark R. Cookson, Michael E. Ward, Yue A. Qi

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14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state حسب Juliana A. Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D. Metcalfe, Mark R. Cookson, Ping Zhang

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. حسب Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle

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Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. حسب Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howell

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A Xeno-Free Protocol for Rapid Differentiation of Human iPSC-Derived Microglia from the KOLF2.1J Reference Line حسب Nélio A. J. Oliveira, Katherine R. Lewkowicz, Patricia A. Clow, Michael E. Ward, Mark R. Cookson, William C. Skarnes, Justin A. McDonough

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Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2 حسب Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay

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Differential microglial responses to structurally distinct alpha-synuclein polymorphs حسب Katherine Chang, Jina Kim, Michiyo Iba, Jae-Hyeon Park, Alexandria Beilina, Zulfeqhar A. Syed, Valentina Baena, Liam Horan-Portelance, Mark R. Cookson, Sungyong You, Changyoun Kim

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Generation of Blood Vascular Endothelial-Neural 3D Organoids by Serial Induction of Differentiation on Human iPSC-Derived Embryoid Bodies حسب Tongguang Wang, Anna Bagnell, Valerie McDonald, Benjamin D. Gastfriend, Joseph P. Steiner, Abdel G. Elkahloun, Kory Johnson, Rebekah G. Langston, Mark R. Cookson, Avindra Nath

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Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues حسب Lucia Iannotta, Alice Biosa, Jillian H. Kluss, Giulia Tombesi, Alice Kaganovich, Susanna Cogo, Nicoletta Plotegher, Laura Civiero, Evy Lobbestael, Veerle Baekelandt, Mark R. Cookson, Elisa Greggio

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Decreased SNCA expression in whole-blood RNA analysis of Parkinson’s disease adjusting for neutrophils حسب Kayla Y. Xu, Ivo Violich, Elizabeth Hutchins, Eric Alsop, Mike A. Nalls, Anni Moore, Cornelis Blauwendraat, J. Raphael Gibbs, Mark R. Cookson, Kendall Van Keuren-Jensen, David W. Craig

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. حسب Anna Sandebring, Kelly Jean Thomas, Alexandra Beilina, Marcel van der Brug, Megan M Cleland, Rili Ahmad, David W Miller, Ibardo Zambrano, Richard F Cowburn, Homira Behbahani, Angel Cedazo-Mínguez, Mark R Cookson

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LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes حسب Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa

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A fully automated FAIMS-DIA mass spectrometry-based proteomic pipeline حسب Luke Reilly, Erika Lara, Daniel Ramos, Ziyi Li, Caroline B. Pantazis, Julia Stadler, Marianita Santiana, Jessica Roberts, Faraz Faghri, Ying Hao, Mike A. Nalls, Priyanka Narayan, Yansheng Liu, Andrew B. Singleton, Mark R. Cookson, Michael E. Ward, Yue A. Qi

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