And four equals one: Presenilin takes the γ-secretase role by itself

av Lessard, Christian B., Wagner, Steven L., Koo, Edward H.
Publicerad 2010

ACRBP (Sp32) is involved in priming sperm for the acrosome reaction and the binding of sperm to the zona pellucida in a porcine model

av Kato, Yoku, Kumar, Satheesh, Lessard, Christian, Bailey, Janice L.
I publikationen PLoS One (2021)

Galactose and Lactose Genes from the Galactose-Positive Bacterium Streptococcus salivarius and the Phylogenetically Related Galactose-Negative Bacterium Streptococcus thermophilus:...

av Vaillancourt, Katy, Moineau, Sylvain, Frenette, Michel, Lessard, Christian, Vadeboncoeur, Christian
Publicerad 2002

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

av Lessard, Christian B., Cottrell, Barbara A., Maruyama, Hiroko, Suresh, Suraj, Golde, Todd E., Koo, Edward H.
I publikationen PLoS One (2015)

Phosphorylation of Streptococcus salivarius Lactose Permease (LacS) by HPr(His∼P) and HPr(Ser-P)(His∼P) and Effects on Growth

av Lessard, Christian, Cochu, Armelle, Lemay, Jean-Dominique, Roy, Denis, Vaillancourt, Katy, Frenette, Michel, Moineau, Sylvain, Vadeboncoeur, Christian
Publicerad 2003

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

av Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
I publikationen J Biol Chem (2019)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

av Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
I publikationen Alzheimers Res Ther (2020)

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

av Sagi, Sarah A., Lessard, Christian B., Winden, Kellen D., Maruyama, Hiroko, Koo, Jeremy C., Weggen, Sascha, Kukar, Thomas L., Golde, Todd E., Koo, Edward H.
Publicerad 2011

γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

av Ran, Yong, Hossain, Fokhrul, Pannuti, Antonio, Lessard, Christian B, Ladd, Gabriela Z, Jung, Joo In, Minter, Lisa M, Osborne, Barbara A, Miele, Lucio, Golde, Todd E
I publikationen EMBO Mol Med (2017)

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

av Magno, Lorenza, Lessard, Christian B., Martins, Marta, Lang, Verena, Cruz, Pedro, Asi, Yasmine, Katan, Matilda, Bilsland, Jamie, Lashley, Tammaryn, Chakrabarty, Paramita, Golde, Todd E., Whiting, Paul J.
I publikationen Alzheimers Res Ther (2019)

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions

av Croft, Cara L., Goodwin, Marshall S., Ryu, Daniel H., Lessard, Christian B., Tejeda, Giancarlo, Marrero, Marc, Vause, Ava R., Paterno, Giavanna, Cruz, Pedro E., Lewis, Jada, Giasson, Benoit I., Golde, Todd E.
I publikationen Acta Neuropathol (2021)

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

av Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
I publikationen EMBO Mol Med (2018)