Resultados da busca - Kyle W Sloop

Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity? por Ellen Conceição-Furber, Tamer Coskun, Kyle W. Sloop, Ricardo J. Samms

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Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain. por Graham M West, Francis S Willard, Kyle W Sloop, Aaron D Showalter, Bruce D Pascal, Patrick R Griffin

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A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor. por Lucy S Jun, Aaron D Showalter, Nosher Ali, Feihan Dai, Wenzhen Ma, Tamer Coskun, James V Ficorilli, Michael B Wheeler, M Dodson Michael, Kyle W Sloop

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Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor. por Lucy S Jun, Aaron D Showalter, Nosher Ali, Feihan Dai, Wenzhen Ma, Tamer Coskun, James V Ficorilli, Michael B Wheeler, M Dodson Michael, Kyle W Sloop

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β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice por Darline Garibay, Jon Lou, Seon A. Lee, Karolina E. Zaborska, Margot H. Weissman, Erica Sloma, Leanne Donahue, Andrew D. Miller, Andrew C. White, M. Dodson Michael, Kyle W. Sloop, Bethany P. Cummings

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Characterization of LY3324954 a long-acting glucagon-receptor agonist por William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger

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Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue por Ricardo J. Samms, GuoFang Zhang, Wentao He, Olga Ilkayeva, Brian A. Droz, Steven M. Bauer, Cynthia Stutsman, Valentina Pirro, Kyla A. Collins, Ellen C. Furber, Tamer Coskun, Kyle W. Sloop, Joseph T. Brozinick, Christopher B. Newgard

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Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation por Shiqian Chen, Carolina B. Lobato, Carissa Wong, Yusman Manchanda, Katrina Viloria, Iona Davies, Daniel B. Andersen, Julia Ast, Kyle W. Sloop, David J. Hodson, Johannes Broichhagen, Steve Bloom, Jens J. Holst, Tricia Tan, Alejandra Tomas, Ben Jones

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Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studies por William Roell, Jorge Alsina-Fernandez, Hongchang Qu, Tamer Coskun, Charles Benson, Axel Haupt, Ronan P. Kelly, Libbey O'Farrell, Kyle W. Sloop, James P. Steele, James Ficorilli, Ajit Regmi, Mallikarjuna Rettiganti, Shweta Urva, Kieren J. Mather, Edward Pratt

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GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells por Mridusmita Saikia, Marlena M. Holter, Leanne R. Donahue, Isaac S. Lee, Qiaonan C. Zheng, Journey L. Wise, Jenna E. Todero, Daryl J. Phuong, Darline Garibay, Reilly Coch, Kyle W. Sloop, Adolfo Garcia-Ocana, Charles G. Danko, Bethany P. Cummings

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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept por Tamer Coskun, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister B. Bokvist, Xuewei Cui, Daniel A. Briere, Over Cabrera, William C. Roell, Uma Kuchibhotla, Julie S. Moyers, Charles T. Benson, Ruth E. Gimeno, David A. D'Alessio, Axel Haupt

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CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis por Kacey J. Prentice, Stacy G. Wendell, Ying Liu, Judith A. Eversley, Sonia R. Salvatore, Haneesha Mohan, Sydney L. Brandt, Andrew C. Adams, X. Serena Wang, David Wei, Garret A. FitzGerald, Timothy B. Durham, Craig D. Hammond, Kyle W. Sloop, Carsten Skarke, Francisco J. Schopfer, Michael B. Wheeler

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist por Francis S. Willard, Jonathan D. Douros, Maria B.N. Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, Wijnand J.C. van der Velden, Cynthia Stutsman, Guemalli R. Cardona, Shweta Urva, Paul J. Emmerson, Jens J. Holst, David A. D’Alessio, Matthew P. Coghlan, Mette M. Rosenkilde, Jonathan E. Campbell, Kyle W. Sloop

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Glucose-dependent insulinotropic polypeptide (GIP) por Timo D. Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L. Birkenfeld, Jonathan E. Campbell, Matthew P. Coghlan, David D'Alessio, Carolyn F. Deacon, Stefano DelPrato, Jonathan D. Douros, Daniel J. Drucker, Natalie S. Figueredo Burgos, Peter R. Flatt, Brian Finan, Ruth E. Gimeno, Fiona M. Gribble, Matthew R. Hayes, Christian Hölscher, Jens J. Holst, Patrick J. Knerr, Filip K. Knop, Christine M. Kusminski, Arkadiusz Liskiewicz, Guillaume Mabilleau, Stephanie A. Mowery, Michael A. Nauck, Aaron Novikoff, Frank Reimann, Anna G. Roberts, Mette M. Rosenkilde, Ricardo J. Samms, Philip E. Scherer, Randy J. Seeley, Kyle W. Sloop, Christian Wolfrum, Denise Wootten, Richard D. DiMarchi, Matthias H. Tschöp

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