Phomopsis sp anti-inflammatory activity antibacterial activity biological activities co-culture deep-sea fungus mangrove endophytic fungi mangrove endophytic fungus marine fungus marine microorganisms marine sponge-associated fungus natural products polyketide polyketides 5-p-hydroxy-2-pyridone AChE inhibitory Aspergillaceae Aspergillus Aspergillus chevalieri Aspergillus insulicola Aspergillus nomius Aspergillus oryzae Aspergillus sclerotiorum Aspergillus versicolor COX-2 inhibition Cochliobolus lunatus Diaporthe sp Dyslexia ECD calculations