Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

Por Hu Jim, Chow Yu-Hua, Hyde Stephen C, Gill Deborah R, Smith Rbecca L, Painter Hazel, Somerton Luci, Singh Charanjit, Farley Raymond, Garcia Sara, Kitson Chris, Griesenbach Uta, Gray Mike, Edbrooke Mark, Ogilvie Varrie, MacGregor Gordon, Scheule Ronald K, Cheng Seng H, Caplen Natasha J, Alton Eric WFW
Publicado em 2006-02-01

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

Por Kamola, Piotr J., Maratou, Klio, Wilson, Paul A., Rush, Kay, Mullaney, Tanya, McKevitt, Tom, Evans, Paula, Ridings, Jim, Chowdhury, Probash, Roulois, Aude, Fairchild, Ann, McCawley, Sean, Cartwright, Karen, Gooderham, Nigel J., Gant, Timothy W., Moores, Kitty, Hughes, Stephen A., Edbrooke, Mark R., Clark, Kenneth, Parry, Joel D.
Publicado no Mol Ther Nucleic Acids (2017)

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

Por Griesenbach, Uta, Kitson, Chris, Garcia, Sara Escudero, Farley, Raymond, Singh, Charanjit, Somerton, Luci, Painter, Hazel, Smith, Rbecca L, Gill, Deborah R, Hyde, Stephen C, Chow, Yu-Hua, Hu, Jim, Gray, Mike, Edbrooke, Mark, Ogilvie, Varrie, MacGregor, Gordon, Scheule, Ronald K, Cheng, Seng H, Caplen, Natasha J, Alton, Eric WFW
Publicado em 2006

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

Por Kamola, Piotr J., Kitson, Jeremy D. A., Turner, Gemma, Maratou, Klio, Eriksson, Sofie, Panjwani, Aliza, Warnock, Linda C., Douillard Guilloux, Gaelle A., Moores, Kitty, Koppe, Emma L., Wixted, William E., Wilson, Paul A., Gooderham, Nigel J., Gant, Timothy W., Clark, Kenneth L., Hughes, Stephen A., Edbrooke, Mark R., Parry, Joel D.
Publicado no Nucleic Acids Res (2015)

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Por Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R
Publicado em 2013