Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein

by Neddermann, Petra, Clementi, Angelica, De Francesco, Raffaele
Published 1999

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

by Bressanelli, Stéphane, Tomei, Licia, Rey, Félix A., De Francesco, Raffaele
Published 2002

Selection of RNA Aptamers That Are Specific and High-Affinity Ligands of the Hepatitis C Virus RNA-Dependent RNA Polymerase

by Biroccio, Antonino, Hamm, Jörg, Incitti, Ilario, De Francesco, Raffaele, Tomei, Licia
Published 2002

Naturally Occurring Hepatitis C Virus Subgenomic Deletion Mutants Replicate Efficiently in Huh-7 Cells and Are trans-Packaged In Vitro To Generate Infectious Defective Particles

by Pacini, Laura, Graziani, Rita, Bartholomew, Linda, De Francesco, Raffaele, Paonessa, Giacomo
Published 2009

The α Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation

by Quintavalle, Manuela, Sambucini, Sonia, Di Pietro, Chiara, De Francesco, Raffaele, Neddermann, Petra
Published 2006

Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

by Powdrill, Megan H., Deval, Jerome, Narjes, Frank, De Francesco, Raffaele, Götte, Matthias
Published 2010

Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus

by Gallinari, Paola, Brennan, Debra, Nardi, Chiara, Brunetti, Mirko, Tomei, Licia, Steinkühler, Christian, De Francesco, Raffaele
Published 1998

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR

by Neddermann, Petra, Gargioli, Cesare, Muraglia, Ester, Sambucini, Sonia, Bonelli, Fabio, De Francesco, Raffaele, Cortese, Riccardo
Published 2003

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR (EMBO reports, February 2003) (Erratum)

by Neddermann, Petra, Gargioli, Cesare, Muraglia, Ester, Sambucini, Sonia, Bonelli, Fabio, De Francesco, Raffaele, Cortese, Riccardo
Published 2003

Oxysterol-Binding Protein is a Phosphatidylinositol 4-kinase Effector Required for HCV Replication Membrane Integrity and Cholesterol Trafficking

by WANG, HONGLIANG, PERRY, JEFFREY W., LAURING, ADAM S., NEDDERMANN, PETRA, DE FRANCESCO, RAFFAELE, TAI, ANDREW W.
Published 2014

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

by Geginat, Jens, Paroni, Moira, Pagani, Massimiliano, Galimberti, Daniela, De Francesco, Raffaele, Scarpini, Elio, Abrignani, Sergio
Published in Trends Immunol (2017)

The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA

by Vannini, Alessandro, Volpari, Cinzia, Gargioli, Cesare, Muraglia, Ester, Cortese, Riccardo, De Francesco, Raffaele, Neddermann, Petra, Di Marco, Stefania
Published 2002

Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture

by Neddermann, Petra, Quintavalle, Manuela, Di Pietro, Chiara, Clementi, Angelica, Cerretani, Mauro, Altamura, Sergio, Bartholomew, Linda, De Francesco, Raffaele
Published 2004

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

by Bressanelli, Stéphane, Tomei, Licia, Roussel, Alain, Incitti, Ilario, Vitale, Rosa Letizia, Mathieu, Magali, De Francesco, Raffaele, Rey, Félix A.
Published 1999

Selection of Functional Variants of the NS3-NS4A Protease of Hepatitis C Virus by Using Chimeric Sindbis Viruses

by Filocamo, Gessica, Pacini, Laura, Nardi, Chiara, Bartholomew, Linda, Scaturro, Maria, Delmastro, Paola, Tramontano, Anna, De Francesco, Raffaele, Migliaccio, Giovanni
Published 1999

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8–substrate complex

by Vannini, Alessandro, Volpari, Cinzia, Gallinari, Paola, Jones, Philip, Mattu, Marco, Carfí, Andrea, De Francesco, Raffaele, Steinkühler, Christian, Di Marco, Stefania
Published 2007

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

by Bianco, Annalisa, Reghellin, Veronica, Donnici, Lorena, Fenu, Simone, Alvarez, Reinaldo, Baruffa, Chiara, Peri, Francesco, Pagani, Massimiliano, Abrignani, Sergio, Neddermann, Petra, De Francesco, Raffaele
Published 2012

Cirrhosis and Rapid Virological Response to Peginterferon Plus Ribavirin Determine Treatment Outcome in HCV-1 IL28B rs12979860 CC Patients

by Aghemo, Alessio, Degasperi, Elisabetta, Rumi, Maria Grazia, Galmozzi, Enrico, Valenti, Luca, De Francesco, Raffaele, De Nicola, Stella, Cheroni, Cristina, Grassi, Eleonora, Colombo, Massimo
Published 2013

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

by Benzine, Tiffany, Brandt, Ryan, Lovell, William C., Yamane, Daisuke, Neddermann, Petra, De Francesco, Raffaele, Lemon, Stanley M., Perelson, Alan S., Ke, Ruian, McGivern, David R.
Published in PLoS Pathog (2017)

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

by Trozzi, Caterina, Bartholomew, Linda, Ceccacci, Alessandra, Biasiol, Gabriella, Pacini, Laura, Altamura, Sergio, Narjes, Frank, Muraglia, Ester, Paonessa, Giacomo, Koch, Uwe, De Francesco, Raffaele, Steinkuhler, Christian, Migliaccio, Giovanni
Published 2003