Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

Autor Jan Glaser, Uta Schurigt, Brian M. Suzuki, Conor R. Caffrey, Ulrike Holzgrabe
Vydáno 2015-06-01

Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.

Autor Maha-Hamadien Abdulla, Kee-Chong Lim, Mohammed Sajid, James H McKerrow, Conor R Caffrey
Vydáno 2007-01-01

Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.

Autor Liliana Rojo-Arreola, Thavy Long, Dan Asarnow, Brian M Suzuki, Rahul Singh, Conor R Caffrey
Vydáno 2014-01-01

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystati...

Autor Hana Dvořáková, Roman Leontovyč, Tomáš Macháček, Anthony J. O'Donoghue, Ondřej Šedo, Zbyněk Zdráhal, Charles S. Craik, Conor R. Caffrey, Petr Horák, Libor Mikeš
Vydáno 2020-02-01

TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling

Autor Alan R. Wolfe, R. Jeffrey Neitz, Mark Burlingame, Brian M. Suzuki, KC Lim, Mark Scheideler, David L. Nelson, Leslie Z. Benet, Conor R. Caffrey
Vydáno 2018-12-01

Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty

Autor Snigdha Singh, Nelly El-Sakkary, Danielle E. Skinner, Prem Prakash Sharma, Sabine Ottilie, Yevgeniya Antonova-Koch, Prashant Kumar, Elizabeth Winzeler, Poonam, Conor R. Caffrey, Brijesh Rathi
Vydáno 2020-02-01

Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica.

Autor Ileana Corvo, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Alegra Eroy-Reveles, Leda Roche, James H McKerrow, John P Dalton, Charles S Craik, Conor R Caffrey, José F Tort
Vydáno 2013-01-01

Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation.

Autor Yi-Ting Yeh, Danielle E Skinner, Ernesto Criado-Hidalgo, Natalie Shee Chen, Antoni Garcia-De Herreros, Nelly El-Sakkary, Lawrence Liu, Shun Zhang, Adithan Kandasamy, Shu Chien, Juan C Lasheras, Juan C Del Álamo, Conor R Caffrey
Vydáno 2022-03-01