Søgeresultater - Caryl E. Sortwell

Book Review: Transplantation of Neural Tissue into the Spinal Cord af Caryl E. Sortwell Ph.D.

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Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity af Anna C. Stoll, Caryl E. Sortwell

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Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor af Kathryn M. Miller, Natosha M. Mercado, Caryl E. Sortwell

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Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease af Megan F. Duffy, Timothy J. Collier, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, D. Luke Fischer, Anna C. Stoll, Caryl E. Sortwell, Caryl E. Sortwell

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Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival af Deanna M. Marchionini, Timothy J. Collier, Mark R. Pitzer, Caryl E. Sortwell

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BDNF rs10501087, rs1491850 and rs11030094 polymorphisms associated with delayed progression in early-stage Parkinson's disease af D. Luke Fischer, Peggy Auinger, John L. Goudreau, Katrina L. Paumier, Allyson Cole-Strauss, Christopher J. Kemp, Jack W. Lipton, Jack W. Lipton, Caryl E. Sortwell, Caryl E. Sortwell

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Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity af Matthew J. Benskey, Rhyomi C. Sellnow, Ivette M. Sandoval, Ivette M. Sandoval, Caryl E. Sortwell, Caryl E. Sortwell, Jack W. Lipton, Jack W. Lipton, Fredric P. Manfredsson, Fredric P. Manfredsson

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Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats af Eleonora Maries, Jeffrey H. Kordower, Yaping Chu, Timothy J. Collier, Caryl E. Sortwell, Eliza Olaru, Kathleen Shannon, Kathy Steece-Collier

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Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats af Natosha M. Mercado, Carlye Szarowicz, Jennifer A. Stancati, Caryl E. Sortwell, Samuel A. Boezwinkle, Timothy J. Collier, Margaret E. Caulfield, Kathy Steece-Collier

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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition af Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Michael Kubik, Nathan Kuhn, Matthew Benskey, Megan F. Duffy, Kelvin C. Luk, Caryl E. Sortwell

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Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions af Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey

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Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age af Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, Kathy Steece-Collier

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Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration af Timothy J. Collier, Jennifer O'Malley, David J. Rademacher, Jennifer A. Stancati, Kellie A. Sisson, Caryl E. Sortwell, Katrina L. Paumier, Kibrom G. Gebremedhin, Kathy Steece-Collier

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High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. af D Luke Fischer, Timothy J Collier, Allyson Cole-Strauss, Susan L Wohlgenant, Jack W Lipton, Kathy Steece-Collier, Fredric P Manfredsson, Christopher J Kemp, Caryl E Sortwell

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Impact of age and vector construct on striatal and nigral transgene expression af Nicole K Polinski, Fredric P Manfredsson, Matthew J Benskey, D Luke Fischer, Christopher J Kemp, Kathy Steece-Collier, Ivette M Sandoval, Katrina L Paumier, Caryl E Sortwell

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The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. af Nicholas M Kanaan, Timothy J Collier, Allyson Cole-Strauss, Tessa Grabinski, Zachary R Mattingly, Mary E Winn, Kathy Steece-Collier, Caryl E Sortwell, Fredric P Manfredsson, Jack W Lipton

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Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS af Nicholas M. Kanaan, Rhyomi C. Sellnow, Sanford L. Boye, Ben Coberly, Antonette Bennett, Mavis Agbandje-McKenna, Caryl E. Sortwell, William W. Hauswirth, Shannon E. Boye, Fredric P. Manfredsson

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Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. af Sara E Gombash, Fredric P Manfredsson, Christopher J Kemp, Nathan C Kuhn, Sheila M Fleming, Ann E Egan, Laura M Grant, Michelle R Ciucci, Jeffrey P MacKeigan, Caryl E Sortwell

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Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents af Nicole K. Polinski, Laura A. Volpicelli-Daley, Caryl E. Sortwell, Kelvin C. Luk, Nunilo Cremades, Lindsey M. Gottler, Jessica Froula, Megan F. Duffy, Virginia M.Y. Lee, Terina N. Martinez, Kuldip D. Dave

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The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats af Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier

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