Ngā hua rapu - Beat Bornhauser

P331: THE ONCOGENIC TRANSCRIPTION FACTOR TCF3::HLF MARKS A DISTINCT ENHANCER-PROMOTER INTERACTION NETWORK IN T(17;19) POSITIVE CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA mā Valdemar Priebe, Aneta Drakul, Stefan Zeyen, Beat Bornhauser, Raffaella Santoro, Jean-Pierre Bourquin

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Rapid Generation of Leukemogenic Chromosomal Translocations in Vivo Using CRISPR/Cas9 mā Yun Huang, Blerim Marovca, Susanne Dettwiler, Peter Karl Bode, Beat Bornhauser, Jean-Pierre Bourquin

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MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling mā Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K. Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin

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High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors mā Lenka Besse, Andrej Besse, Marianne Kraus, Elmer Maurits, Herman S. Overkleeft, Beat Bornhauser, Jean-Pierre Bourquin, Christoph Driessen

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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9 mā Lena Behrmann, Scott McComb, Júlia Aguadé-Gorgorió, Yun Huang, Mario Hermann, Pawel Pelczar, Adriano Aguzzi, Jean Bourquin, Beat Bornhauser

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BH3-MIMETIC TREATMENT REVEALS SUBTYPE-SPECIFIC BCL-2 PROTEIN DEPENDENCY IN PEDIATRIC MDS WITH EXCESS BLASTS mā Sheila Bohler, Ayami Yoshimi Nöllke, Nastassja Scheidegger, Ben Haladik, Beat Bornhauser, Michael N. Dworzak, Kaan Boztug, Markus Schmugge, Charlotte M. Niemeyer, Miriam Erlacher

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Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells mā Juliane Mietz, Lukas Egli, Meike Misiune, Arianna Picozzi, Nicolò Coianiz, Danielle Thompson, Marianna Ponzo, Alisson Charmey, Beat Bornhauser, Chiara F. Magnani, Christian Münz, Obinna Chijioke

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Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia mā Julia Costea, Kerstin K. Rauwolf, Pietro Zafferani, Tobias Rausch, Anna Mathioudaki, Judith Zaugg, Martin Schrappe, Cornelia Eckert, Gabriele Escherich, Jean P. Bourquin, Beat Bornhauser, Andreas E. Kulozik, Jan O. Korbel

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Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia mā Marketa Zaliova, Eliska Potuckova, Julius Lukes, Lucie Winkowska, Julia Starkova, Iveta Janotova, Lucie Sramkova, Jan Stary, Jan Zuna, Martin Stanulla, Martin Zimmermann, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Gunnar Cario, Jan Trka

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B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow mā Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin

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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response mā Nurul Khalida Ibrahim, Sabine Schreek, Buesra Cinar, Anna Sophie Stasche, Su Hyun Lee, Andre Zeug, Tim Dolgner, Julia Niessen, Evgeni Ponimaskin, Halyna Shcherbata, Beate Fehlhaber, Jean-Pierre Bourquin, Beat Bornhauser, Martin Stanulla, Andreas Pich, Alejandro Gutierrez, Laura Hinze

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Functional precision approach in patients with very high risk acute lymphoblastic leukaemia in India: a single-centre cohort studyResearch in context mā Jasmeet Sidhu, Arijit Chakraborty, Parag Das, Fabio D. Steffen, Subhajit Kundu, Sangramjit Basu, Bhaswati Tarafdar, Tanima Dey, Abhirupa Kar, Mousumi Biswas, Ankita Das, Naveen Sivadasan, Pritha Dasgupta, Niharendu Ghara, Beat Bornhauser, Jean-Pierre Bourquin, Shekhar Krishnan, Vaskar Saha

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P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS mā Rebecca Hasselmann, Lena Blümel, Flavia Bernardi, Daniel Picard, Jacob Torrejon-Diaz, Vera Jepsen, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovca, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourquin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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ADVANCED DRUG RESPONSE PROFILING AND IMMUNOPHENOTYPING TO PRIORITIZE TREATMENT OPTIONS FOR PEDIATRIC MDS WITH EXCESS BLASTS mā Ben Haladik, Margarita Maurer-Granofszky, Anna Hurt, Claudia M. Koelbl, Nastassja Scheidegger, Silvia Gutnik, Fabio Steffen, Barbara De Moerloose, Henrik Hasle, Marek Ussowicz, Luca Vinci, Ayami Yoshimi Noellke, Jean-Pierre Bourquin, Charlotte Niemeyer, Markus Schmugge, Beat Bornhauser, Miriam Erlacher, Michael N. Dworzak, Kaan Boztug

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Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12 mā Selina Troester, Thomas Eder, Nadja Wukowits, Martin Piontek, Pablo Fernández-Pernas, Johannes Schmoellerl, Ben Haladik, Gabriele Manhart, Melanie Allram, Margarita Maurer-Granofszky, Nastassja Scheidegger, Karin Nebral, Giulio Superti-Furga, Roland Meisel, Beat Bornhauser, Peter Valent, Michael N. Dworzak, Johannes Zuber, Kaan Boztug, Florian Grebien

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Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia mā Lena Blumel, Flavia Bernardi, Daniel Picard, Jacob Torrejon Diaz, Vera H. Jepsen, Rebecca Hasselmann, Julian Schliehe-Diecks, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovka, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourqin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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INTEGRATED IMMUNOPHENOTYPING AND DRUG RESPONSE PROFILING REVEALS SUBTYPE-SPECIFIC SUSCEPTIBILITIES IN PEDIATRIC MDS WITH EXCESS BLASTS mā Nastassja Scheidegger-Egloff, Silvia Gutnik, Claudia Moeller, Fabio Steffen, Arianna Arpagaus, Larissa Schori, Selina Schuehle, Sheila Bohler, Ben Haladik, Anna Hurt, Claudia M. Koebl, Margarita Maurer Granofszky, Barbara De Moerloose, Henrik Hasle, Charlotte Niemeyer, Marek Ussowicz, Luca Vinci, Ayami Yoshimi-Noellke, Kaan Boztug, Michael N. Dworzak, Jean-Pierre Bourquin, Miriam Erlacher, Markus Schmugge, Beat Bornhauser

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PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia mā Paulina Richter‐Pechańska, Joachim B Kunz, Beat Bornhauser, Caroline von Knebel Doeberitz, Tobias Rausch, Büşra Erarslan‐Uysal, Yassen Assenov, Viktoras Frismantas, Blerim Marovca, Sebastian M Waszak, Martin Zimmermann, Julia Seemann, Margit Happich, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Martina U Muckenthaler, Jan O Korbel, Jean‐Pierre Bourquin, Andreas E Kulozik

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Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors mā Büşra Erarslan‐Uysal, Joachim B Kunz, Tobias Rausch, Paulina Richter‐Pechańska, Ianthe AEM van Belzen, Viktoras Frismantas, Beat Bornhauser, Diana Ordoñez‐Rueada, Malte Paulsen, Vladimir Benes, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Tsvetomir Loukanov, Matthias Gorenflo, Sebastian M Waszak, Jean‐Pierre Bourquin, Martina U Muckenthaler, Jan O Korbel, Andreas E Kulozik

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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse mā Obul R. Bandapalli, Stephanie Schuessele, Joachim B. Kunz, Tobias Rausch, Adrian M. Stütz, Noa Tal, Ifat Geron, Nava Gershman, Shai Izraeli, Juliane Eilers, Nina Vaezipour, Renate Kirschner-Schwabe, Jana Hof, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Martin Zimmermann, Rolf Koehler, Smadar Avigad, Rupert Handgretinger, Viktoras Frismantas, Jean Pierre Bourquin, Beat Bornhauser, Jan O. Korbel, Martina U. Muckenthaler, Andreas E. Kulozik

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