Resultados da busca - Alex Avdeef

Acetylpromazine maleate revisited: deep-dive equilibrium analysis revealing drug salt acting as a pH- and pS-stat counter-titrant por Alex Avdeef

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Anomalous Solubility Behavior of Several Acidic Drugs por Alex Avdeef

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Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH por Alex Avdeef

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In memoriam - Konstantin Tsinman (1968 - 2020) por Alex Avdeef

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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods por Alex Avdeef

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Mechanistically transparent models for predicting aqueous solubility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression por Alex Avdeef

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Anomalous salting-out, self-association and pKa effects in the practically-insoluble bromothymol blue por Alex Avdeef

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Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs por Alex Avdeef

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Solubility Temperature Dependence Predicted from 2D Structure por Alex Avdeef

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Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database por Alex Avdeef

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Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments por Alex Avdeef

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Do you know your r2? por Alex Avdeef

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Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs por Alex Avdeef

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Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation por Alex Avdeef

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Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs? por Alex Avdeef, Manfred Kansy

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Perspectives in solubility measurement and interpretation por Christel A.S. Bergström, Alex Avdeef

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pKa-critical Interpretations of Solubility–pH Profiles: PG 300995 and NSC-639829 Case Studies por George Butcher, John Comer, Alex Avdeef

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Salt Solubility Products of Diprenorphine Hydrochloride, Codeine and Lidocaine Hydrochlorides and Phosphates – Novel Method of Data Analysis Not Dependent on Explicit Solubility Eq... por Gergely Völgyi, Attila Marosi, Krisztina Takács-Novák, Alex Avdeef

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Imipramine solubility-pH profiles: self-aggregation vs. common-ion effect por Olivera S. Marković, Miloš P. Pešić, Alex Avdeef, Abu T. M. Serajuddin, Tatjana Verbić

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Equilibrium solubility measurement of ionizable drugs – consensus recommendations for improving data quality por Alex Avdeef, Elisabet Fuguet, Antonio Llinàs, Clara Ràfols, Elisabeth Bosch, Gergely Völgyi, Tatjana Verbić, Elena Boldyreva, Krisztina Takács-Novák

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