Cell Interactions in Biliary Diseases: Clues from Pathophysiology and Repair Mechanisms to Foster Early Assessment

by Fabris, Luca, Spirli, Carlo, Mertens, Joachim
Published in Int J Mol Sci (2019)

Emerging concepts in biliary repair and fibrosis

by Fabris, Luca, Spirli, Carlo, Cadamuro, Massimiliano, Fiorotto, Romina, Strazzabosco, Mario
Published in Am J Physiol Gastrointest Liver Physiol (2017)

Post-Translational Regulation of Polycystin-2 Protein Expression as a Novel Mechanism of Cholangiocyte Reaction and Repair from Biliary Damage

by Spirli, Carlo, Villani, Ambra, Mariotti, Valeria, Fabris, Luca, Fiorotto, Romina, Strazzabosco, Mario
Published in Hepatology (2015)

Adenylyl Cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in Polycystic Liver Disease

by Spirli, Carlo, Mariotti, Valeria, Villani, Ambra, Fabris, Luca, Fiorotto, Romina, Strazzabosco, Mario
Published in J Hepatol (2016)

Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves CFTR correctors efficacy

by Fiorotto, Romina, Amenduni, Mariangela, Mariotti, Valeria, Fabris, Luca, Spirli, Carlo, Strazzabosco, Mario
Published in Hepatology (2018)

Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases()

by Fiorotto, Romina, Amenduni, Mariangela, Mariotti, Valeria, Fabris, Luca, Spirli, Carlo, Strazzabosco, Mario
Published in Biochim Biophys Acta Mol Basis Dis (2018)

Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma

by Cadamuro, Massimiliano, Brivio, Simone, Spirli, Carlo, Joplin, Ruth E., Strazzabosco, Mario, Fabris, Luca
Published in Int J Mol Sci (2017)

Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB–Mediated Inflammatory Response in Mice

by Fiorotto, Romina, Scirpo, Roberto, Trauner, Michael, Fabris, Luca, Hoque, Rafaz, Spirli, Carlo, Strazzabosco, Mario
Published 2011

Animal models for cystic fibrosis liver disease (CFLD)

by Fiorotto, Romina, Amenduni, Mariangela, Mariotti, Valeria, Cadamuro, Massimiliano, Fabris, Luca, Spirli, Carlo, Strazzabosco, Mario
Published in Biochim Biophys Acta Mol Basis Dis (2018)

Altered Store Operated Calcium Entry Increases cAMP production and ERK1/2 phosphorylation in Polycystin-2 Defective Cholangiocytes

by Spirli, Carlo, Locatelli, Luigi, Fiorotto, Romina, Morell, Carola M., Fabris, Luca, Pozzan, Tullio, Strazzabosco, Mario
Published 2012

Pathophysiologic implications of innate immunity and autoinflammation in the biliary epithelium

by Strazzabosco, Mario, Fiorotto, Romina, Cadamuro, Massimiliano, Spirli, Carlo, Mariotti, Valeria, Kaffe, Eleanna, Scirpo, Roberto, Fabris, Luca
Published in Biochim Biophys Acta (2017)

The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma()

by Cadamuro, Massimiliano, Stecca, Tommaso, Brivio, Simone, Mariotti, Valeria, Fiorotto, Romina, Spirli, Carlo, Strazzabosco, Mario, Fabris, Luca
Published in Biochim Biophys Acta Mol Basis Dis (2017)

Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice

by Fiorotto, Romina, Raizner, Aileen, Morell, Carola M., Torsello, Barbara, Scirpo, Roberto, Fabris, Luca, Spirli, Carlo, Strazzabosco, Mario
Published 2013

MAMMALIAN TARGET OF RAPAMYCIN REGULATES VASCULAR ENDOTHELIAL GROWTH FACTOR-DEPENDENT LIVER CYSTS GROWTH IN POLYCYSTIN-2 DEFECTIVE MICE

by Spirli, Carlo, Okolicsanyi, Stefano, Fiorotto, Romina, Fabris, Luca, Cadamuro, Massimiliano, Lecchi, Silvia, Tian, Xin, Somlo, Stefan, Strazzabosco, Mario
Published 2010

PKA dependent p-Ser-(675)β-catenin, a novel signaling defect in a mouse model of Congenital Hepatic Fibrosis

by Spirli, Carlo, Locatelli, Luigi, Morell, Carola M., Fiorotto, Romina, Morton, Stuart D., Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario
Published 2013

β-catenin and IL-1β dependent CXCL10 production drives progression of disease in a mouse model of Congenital Hepatic Fibrosis

by Kaffe, Eleanna, Fiorotto, Romina, Pellegrino, Francesca, Mariotti, Valeria, Amenduni, Mariangela, Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario, Spirli, Carlo
Published in Hepatology (2018)

Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases

by Fabris, Luca, Fiorotto, Romina, Spirli, Carlo, Cadamuro, Massimiliano, Mariotti, Valeria, Perugorria, Maria J., Banales, Jesus M., Strazzabosco, Mario
Published in Nat Rev Gastroenterol Hepatol (2019)

Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib

by Spirli, Carlo, Morell, Carola M., Locatelli, Luigi, Okolicsanyi, Stefano, Ferrero, Cecilia, Kim, Amy K., Fabris, Luca, Fiorotto, Romina, Strazzabosco, Mario
Published 2012

Analysis of Liver Repair Mechanisms in Alagille Syndrome and Biliary Atresia Reveals a Role for Notch Signaling

by Fabris, Luca, Cadamuro, Massimiliano, Guido, Maria, Spirli, Carlo, Fiorotto, Romina, Colledan, Michele, Torre, Giuliano, Alberti, Daniele, Sonzogni, Aurelio, Okolicsanyi, Lajos, Strazzabosco, Mario
Published 2007

Low dose paclitaxel reduces S100A4 nuclear import to inhibit invasion and hematogenous metastasis of cholangiocarcinoma

by Cadamuro, Massimiliano, Spagnuolo, Gaia, Sambado, Luisa, Indraccolo, Stefano, Nardo, Giorgia, Rosato, Antonio, Brivio, Simone, Caslini, Chiara, Stecca, Tommaso, Massani, Marco, Bassi, Nicolò, Novelli, Eugenio, Spirli, Carlo, Fabris, Luca, Strazzabosco, Mario
Published in Cancer Res (2016)