ESR1 mutations as a mechanism for acquired endocrine resistance in breast cancer

by Jeselsohn, Rinath, Buchwalter, Gilles, De Angelis, Carmine, Brown, Myles, Schiff, Rachel
Published in Nat Rev Clin Oncol (2015)

The Changing Role of ER in Endocrine Resistance

by Nardone, Agostina, De Angelis, Carmine, Trivedi, Meghana V., Osborne, C. Kent, Schiff, Rachel
Published in Breast (2015)

PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells

by Ito, Koichi, Park, Sun Hee, Katsyv, Igor, Zhang, Weijia, De Angelis, Carmine, Schiff, Rachel, Irie, Hanna Y.
Published in NPJ Breast Cancer (2017)

Towards personalized treatment for early stage HER2-positive breast cancer

by Goutsouliak, Kristina, Veeraraghavan, Jamunarani, Sethunath, Vidyalakshmi, De Angelis, Carmine, Osborne, C. Kent, Rimawi, Mothaffar F., Schiff, Rachel
Published in Nat Rev Clin Oncol (2019)

Immune Response Against Head and Neck Cancer: Biological Mechanisms and Implication on Therapy

by Perri, Francesco, Ionna, Franco, Longo, Francesco, Della Vittoria Scarpati, Giuseppina, De Angelis, Carmine, Ottaiano, Alessandro, Botti, Gerardo, Caponigro, Francesco
Published in Transl Oncol (2019)

De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance

by Veeraraghavan, Jamunarani, De Angelis, Carmine, Reis-Filho, Jorge S., Prat, Aleix, Rimawi, Mothaffar F., Pascual, Tomás, Osborne, C. Kent, Schiff, Rachel
Published in Breast (2017)

What Medical Oncologist Residents Think about the Italian Speciality Schools: A Survey of the Italian Association of Medical Oncology (AIOM) on Educational, Clinical and Research A...

by Moretti, Anna, Ghidini, Michele, De Angelis, Carmine, Lambertini, Matteo, Cremolini, Chiara, Imbimbo, Martina, Berardi, Rossana, Di Maio, Massimo, Cascinu, Stefano, La Verde, Nicla
Published in PLoS One (2016)

Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer

by Guarducci, Cristina, Bonechi, Martina, Benelli, Matteo, Biagioni, Chiara, Boccalini, Giulia, Romagnoli, Dario, Verardo, Roberto, Schiff, Rachel, Osborne, C. Kent, De Angelis, Carmine, Di Leo, Angelo, Malorni, Luca, Migliaccio, Ilenia
Published in NPJ Breast Cancer (2018)

A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer

by Abdulkareem, Noor Mazin, Bhat, Raksha, Qin, Lanfang, Vasaikar, Suhas, Gopinathan, Ambily, Mitchell, Tamika, Shea, Martin J., Nanda, Sarmistha, Thangavel, Hariprasad, Zhang, Bing, De Angelis, Carmine, Schiff, Rachel, Trivedi, Meghana V.
Published in FASEB J (2021)

Case Report: Detection of a Novel Germline PALB2 Deletion in a Young Woman With Hereditary Breast Cancer: When the Patient's Phenotype History Doesn't Lie

by De Angelis, Carmine, Nardelli, Carmela, Concolino, Paola, Pagliuca, Martina, Setaro, Mario, De Paolis, Elisa, De Placido, Pietro, Forestieri, Valeria, Scaglione, Giovanni Luca, Ranieri, Annalisa, Lombardo, Barbara, Pastore, Lucio, De Placido, Sabino, Capoluongo, Ettore
Published in Front Oncol (2021)

Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity

by Stossi, Fabio, Dandekar, Radhika D, Mancini, Maureen G, Gu, Guowei, Fuqua, Suzanne A W, Nardone, Agostina, De Angelis, Carmine, Fu, Xiaoyong, Schiff, Rachel, Bedford, Mark T, Xu, Wei, Johansson, Hans E, Stephan, Clifford C, Mancini, Michael A
Published in Nucleic Acids Res (2020)

Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and an...

by Ramirez, Arturo B., Bhat, Raksha, Sahay, Debashish, De Angelis, Carmine, Thangavel, Hariprasad, Hedayatpour, Sina, Dobrolecki, Lacey E., Nardone, Agostina, Giuliano, Mario, Nagi, Chandandeep, Rimawi, Mothaffar, Osborne, C. Kent, Lewis, Michael T., Stilwell, Jackie L., Kaldjian, Eric P., Schiff, Rachel, Trivedi, Meghana V.
Published in BMC Cancer (2019)

GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer

by Bhat, Raksha R., Yadav, Puja, Sahay, Debashish, Bhargava, Dharmendra K., Creighton, Chad J., Yazdanfard, Sahar, Al-rawi, Ahmed, Yadav, Vikas, Qin, Lanfang, Nanda, Sarmistha, Sethunath, Vidyalakshmi, Fu, Xiaoyong, De Angelis, Carmine, Narkar, Vihang A., Kent Osborne, C., Schiff, Rachel, Trivedi, Meghana V.
Published in Breast Cancer Res Treat (2018)

The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance

by Nardone, Agostina, Weir, Hazel, Delpuech, Oona, Brown, Henry, De Angelis, Carmine, Cataldo, Maria Letizia, Fu, Xiaoyong, Shea, Martin J., Mitchell, Tamika, Veeraraghavan, Jamunarani, Nagi, Chandandeep, Pilling, Mark, Rimawi, Mothaffar F., Trivedi, Meghana, Hilsenbeck, Susan G., Chamness, Gary C., Jeselsohn, Rinath, Osborne, C. Kent, Schiff, Rachel
Published in Br J Cancer (2018)

Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance

by Malorni, Luca, Giuliano, Mario, Migliaccio, Ilenia, Wang, Tao, Creighton, Chad J., Lupien, Mathieu, Fu, Xiaoyong, Hilsenbeck, Susan G., Healy, Nuala, De Angelis, Carmine, Mazumdar, Abhijit, Trivedi, Meghana V., Massarweh, Suleiman, Gutierrez, Carolina, De Placido, Sabino, Jeselsohn, Rinath, Brown, Myles, Brown, Powel H., Osborne, C. Kent, Schiff, Rachel
Published in Mol Cancer Res (2016)

Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models

by Veeraraghavan, Jamunarani, Gutierrez, Carolina, Sethunath, Vidyalakshmi, Mehravaran, Sepideh, Giuliano, Mario, Shea, Martin J., Mitchell, Tamika, Wang, Tao, Nanda, Sarmistha, Pereira, Resel, Davis, Robert, Goutsouliak, Kristina, Qin, Lanfang, De Angelis, Carmine, Diala, Irmina, Lalani, Alshad S., Nagi, Chandandeep, Hilsenbeck, Susan G., Rimawi, Mothaffar F., Osborne, C. Kent, Schiff, Rachel
Published in NPJ Breast Cancer (2021)

Embryonic transcription factor SOX9 drives breast cancer endocrine resistance

by Jeselsohn, Rinath, Cornwell, MacIntosh, Pun, Matthew, Buchwalter, Gilles, Nguyen, Mai, Bango, Clyde, Huang, Ying, Kuang, Yanan, Paweletz, Cloud, Fu, Xiaoyong, Nardone, Agostina, De Angelis, Carmine, Detre, Simone, Dodson, Andrew, Mohammed, Hisham, Carroll, Jason S., Bowden, Michaela, Rao, Prakash, Long, Henry W., Li, Fugen, Dowsett, Mitchell, Schiff, Rachel, Brown, Myles
Published in Proc Natl Acad Sci U S A (2017)

Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis

by Wu, Yanming, Zhang, Zhao, Cenciarini, Mauro E., Proietti, Cecilia J., Amasino, Matias, Hong, Tao, Yang, Mei, Liao, Yiji, Chiang, Huai-Chin, Kaklamani, Virginia G., Jeselsohn, Rinath, Vadlamudi, Ratna K., Huang, Tim Hui-Ming, Li, Rong, De Angelis, Carmine, Fu, Xiaoyong, Elizalde, Patricia V., Schiff, Rachel, Brown, Myles, Xu, Kexin
Published in Cancer Res (2017)

Enhancer Reprogramming Driven by High-order Assemblies of Transcription Factors Promotes Phenotypic Plasticity and Breast Cancer Endocrine Resistance

by Bi, Mingjun, Zhang, Zhao, Jiang, Yi-Zhou, Xue, Pengya, Wang, Hu, Lai, Zhao, Fu, Xiaoyong, De Angelis, Carmine, Gong, Yue, Gao, Zhen, Ruan, Jianhua, Jin, Victor X., Marangoni, Elisabetta, Montaudon, Elodie, Glass, Christopher K., Li, Wei, Huang, Tim Hui-Ming, Shao, Zhi-Ming, Schiff, Rachel, Chen, Lizhen, Liu, Zhijie
Published in Nat Cell Biol (2020)

Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with anti-HER2 therapy

by Giuliano, Mario, Hu, Huizhong, Wang, Yen-Chao, Fu, Xiaoyong, Nardone, Agostina, Herrera, Sabrina, Mao, Sufeng, Contreras, Alejandro, Gutierrez, Carolina, Wang, Tao, Hilsenbeck, Susan G., De Angelis, Carmine, Wang, Nicholas J., Heiser, Laura M., Gray, Joe W., Lopez-Tarruella, Sara, Pavlick, Anne C., Trivedi, Meghana V., Chamness, Gary C., Chang, Jenny C., Osborne, C. Kent, Rimawi, Mothaffar F., Schiff, Rachel
Published in Clin Cancer Res (2015)