DOTATOC Delphi EMT GEP-NET Ki67 labeling index Ki67 proliferation index MEN2 PET/CT PRRT TPH inhibitors adrenocortical cancer adrenocortical tissues anaplastic thyroid carcinoma angiogenesis avelumab biomarkers calcitonin checkpoint inhibitors chemotherapy circulating cells consensus crcinoid crisis ctDNA epithelial markers everolimus fusion gastroenteropancreatic neuroendocrine neoplasms gene carriers hemodynamic instability immune checkpoint inhibitors